Welcome

journal cover art collage

Journal cover art from the Reynolds group - 2015-2021

Our research interests are broadly defined within three distinct areas:

  • Development and synthesis of new biomedical materials
  • Applied and fundamental studies of Metal-Organic Frameworks (MOFs)
  • Analytical method development

Biomedical materials development includes the synthesis of prodrugs to simultaneously detect and kill bacteria, glucose biosensing, fabrication of biomass-sourced and biodegradable nitric oxide (NO) releasing polymers, the creation of new pediatric cancer therapeutics, and the creation of new materials to improve extracorporeal membrane oxygenation (ECMO). Applied areas of MOF research include the development of next-generation glucose biosensing, fluorescence-based sensing of heavy metals, incorporation of MOFs into biocompatible medical devices, and MOF-based high-performance liquid chromatography (HPLC) separations. Fundamental areas of MOF research include thermal/materials analysis of MOF catalysts, development of flow catalysis systems with MOFs, and kinetic/mechanistic investigations into MOF biocatalysis. Current projects related to analytical method development include generation of liquid chromatography-mass spectrometry (LC-MS) separation and detection methods to analyze the safety and biocompatibility of biodegradable medical devices, fast and easy LC-MS based detection methods for fungal infection biomarkers, and MOF based HPLC separations.

Nitric oxide MOF image

News and Updates

Group News

Group Picture August 2017
Group Picture: August 2017 (New Chemistry Research Building Lab!)

Funding and Award News

Recent Select Publications

Computational Insights into the Mechanism of Nitric Oxide Generation from S-Nitrosoglutathione Catalyzed by a Copper Metal-Organic Framework. Journal of the American Chemical Society. 2023.

Modeling a pesticide remediation strategy for preparative liquid chromatography using high-performance liquid chromatography. Journal of Cannabis Research. 2023.

Surface Modification of Oxygenator Fibers with a Catalytically Active Metal–Organic Framework to Generate Nitric Oxide: An Ex Vivo Pilot Study. ACS Appl. Bio Mater. 2023.

MOF Polymer Composites Exhibit Faster Nitric Oxide Catalysis than MOF Crystallites. ACS Materials Lett. 2022.

CuII Lewis Acid, Proton-Coupled Electron Transfer Mechanism for Cu-Metal-Organic Framework-Catalyzed NO Release from S-Nitrosoglutathione. ACS Catalysis. 2022.

Evaluation of the Adsorption-Accessible Surface Area of MIL-53(Al) using Cannabinoids in a Closed System. ACS Appl. Mater. Inter. 2022.

Systematic Exploration of a Catalytic Metal-Organic Framework/Polyurethane Composite for Medical Device Applications: Effects of MOF Particle Size, MOF Loading, and Polymer Concentration on Composite Material Activity. Frontiers in Physics. 2022.

Cu-Based Metal-Organic Framework Nanosheets Synthesized via a Three-Layer Bottom-Up Method for the Catalytic Conversion of S-Nitrosoglutathione to Nitric Oxide. ACS Appl. Nano Materials. 2021.

Ex Vivo Evaluation of Blood Coagulation of Endothelial Glycocalyx-Inspired Surfaces Using Thromboelastography. In Vitro Models. 2021.

Monitoring a MOF Catalyzed Reaction Directly in Blood Plasma. Anal. Bioanal. Chem. 2021.

Detection of Glucosamine as a Marker for Aspergillus Niger: A Potential Screening Method for Fungal Infections. Anal. Bioanal. Chem. 2021.

Anticancer Potential of Nitric Oxide (NO) in Neuroblastoma Treatment. RSC Adv. 2021.

Blood-Compatible Materials: Vascular Endothelium-Mimetic Surfaces that Mitigate Multiple Cell-Material Interactions Advanced Healthcare Materials. 2021.

Exploring the Parameter Space of p-Cresyl Sulfate Adsorption in Metal-Organic Frameworks. ACS Appl. Mater. Inter. 2020.

Thermogravimetric Analysis and Mass Spectrometry Allow for Determination of Chemisorbed Reaction Products on Metal Organic Frameworks. Langmuir. 2020.

Metal-Organic Framework Polymer Coating Inhibits Staphylococcus aureus Attachment on Medical Circulation Tubing under Static and Dynamic Flow Conditions.  ACS Appl. Bio Mater. 2020.

Research Funding

NIH logo

NSF logo

Boettcher logo

DOD logo

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Contact

E-mail

Melissa.Reynolds@colostate.edu

Mailing Address

Department of Chemistry
Colorado State University
Fort Collins, CO 80523

Telephone

Office: 970-491-3775