Welcome

journal cover art collage

Journal cover art from the Reynolds group - 2015-2021

Our research interests are broadly defined within three distinct areas:

  • Development and synthesis of new biomedical materials
  • Applied and fundamental studies of Metal-Organic Frameworks (MOFs)
  • Analytical method development

Biomedical materials development includes the synthesis of prodrugs to simultaneously detect and kill bacteria, glucose biosensing, fabrication of biomass-sourced and biodegradable nitric oxide (NO) releasing polymers, the creation of new pediatric cancer therapeutics, and the creation of new materials to improve extracorporeal membrane oxygenation (ECMO). Applied areas of MOF research include the development of next-generation glucose biosensing, fluorescence-based sensing of heavy metals, incorporation of MOFs into biocompatible medical devices, and MOF-based high-performance liquid chromatography (HPLC) separations. Fundamental areas of MOF research include thermal/materials analysis of MOF catalysts, development of flow catalysis systems with MOFs, and kinetic/mechanistic investigations into MOF biocatalysis. Current projects related to analytical method development include generation of liquid chromatography-mass spectrometry (LC-MS) separation and detection methods to analyze the safety and biocompatibility of biodegradable medical devices, fast and easy LC-MS based detection methods for fungal infection biomarkers, and MOF based HPLC separations.

Nitric oxide MOF image

News and Updates

Group News

TMBR group members continued their excellent and prolific work throughout (and despite) the COVID pandemic. Since January 2020:

  • Congratulations to our 2021 Grad Showcase winners:
    • Great Minds in Research Award, honorable mention - Jon Thai
    • Graduate Student Council, New Graduate Student Award - Yaman Peksenar
    • Walter Scott, Jr. College of Engineering Excellence in Research Award - Tracey Wick
  • First presentations from the Panacea Life Sciences Cannabinoid Research Center – Jamie Cuchiaro presents two posters at the ICR conference in August 2021.
  • Rob Tuttle, Ryann Daly and Chris Rithner work on MOF reactivity in blood plasma included in a Special Forum - “Emerging Materials for Catalysis and Energy Applications” edition of ACS Applied Materials and Interfaces to Dr. Chia-Kuang Tsung who died from COVID complications (https://www.bc.edu/bc-web/bcnews/campus-community/faculty/in-memoriam-frank-tsung.html).
  • Tracey Wick awarded Outstanding Walter Scott College of Engineering Outstanding Senior Researcher.
  • Kristin Hinsen and Tracey Wick earn Best in Show for their research posters at CURC 2021.
  • Yanyi Zang was awarded a prestigious NRC post doctoral fellowship.
  • Prof. Reynolds named Director of the Panacea Life Sciences Cannabinoid Research Center.
  • Lab expands instrumentation and MOF synthesis capability with the acquisition of an Agilent 1260 HPLC with diode array and refractive index detectors and an auto sampler chiller to control vial temperature 4-50 C, a Horiba Fluorometer, and Mars6 microwave.
  • Prof. Reynolds was appointed to chair the Research Continuity Working Group for the Fort Collins campus.
  • Prof. Reynolds named to the scientific advisory board for the New Hampshire NSF EPSCoR Program grant.
  • For the third consecutive year, Prof. Reynolds participated as an Experienced Academic Leader in the Cottrell Scholars Collaborative Academic Training Workshop.
  • Yanyi Zang, Matt Jones, Rob Tuttle, Jessi Vleck and Jenna Gordon manuscripts highlighted as cover art features in ACS Appl. Bio Mater., Langmuir, ACS Appl. Mater. Interfaces, Adv. Healthc. Mater., and Vet. Sci.
  • In 2020, Yanyi Zang, Hailey Hibbard, Chris Allison, Arnold Paecklar and Jesus Tapia all defended their dissertations. Congratulations to Drs. Zang, Hibbard, Allison, Paecklar and Tapia.
  • In 2021, Rob Tuttle and Jenna Gordon defended their dissertations. Congratulations to Drs. Tuttle and Gordon.
  • Group members Kristin Hinsen, Tracey Wick, Jamie Curchario, Jon Thai and Alyssa Melvin present their research virtually at CURC, the Grad Show Case, ACS National Meeting and the Institute for Cannabis Research Conference.
Group Picture August 2017
Group Picture: August 2017 (New Chemistry Research Building Lab!)

Funding and Award News

Recent Select Publications

CuII Lewis Acid, Proton-Coupled Electron Transfer Mechanism for Cu-Metal-Organic Framework-Catalyzed NO Release from S-Nitrosoglutathione. ACS Catalysis. 2022.

Evaluation of the Adsorption-Accessible Surface Area of MIL-53(Al) using Cannabinoids in a Closed System. ACS Appl. Mater. Inter. 2022.

Systematic Exploration of a Catalytic Metal-Organic Framework/Polyurethane Composite for Medical Device Applications: Effects of MOF Particle Size, MOF Loading, and Polymer Concentration on Composite Material Activity. Frontiers in Physics. 2022.

Cu-Based Metal-Organic Framework Nanosheets Synthesized via a Three-Layer Bottom-Up Method for the Catalytic Conversion of S-Nitrosoglutathione to Nitric Oxide. ACS Appl. Nano Materials. 2021.

Ex Vivo Evaluation of Blood Coagulation of Endothelial Glycocalyx-Inspired Surfaces Using Thromboelastography. In Vitro Models. 2021.

Monitoring a MOF Catalyzed Reaction Directly in Blood Plasma. Anal. Bioanal. Chem. 2021.

Detection of Glucosamine as a Marker for Aspergillus Niger: A Potential Screening Method for Fungal Infections. Anal. Bioanal. Chem. 2021.

Anticancer Potential of Nitric Oxide (NO) in Neuroblastoma Treatment. RSC Adv. 2021.

Blood-Compatible Materials: Vascular Endothelium-Mimetic Surfaces that Mitigate Multiple Cell-Material Interactions Advanced Healthcare Materials. 2021.

Exploring the Parameter Space of p-Cresyl Sulfate Adsorption in Metal-Organic Frameworks. ACS Appl. Mater. Inter. 2020.

Thermogravimetric Analysis and Mass Spectrometry Allow for Determination of Chemisorbed Reaction Products on Metal Organic Frameworks. Langmuir. 2020.

Metal-Organic Framework Polymer Coating Inhibits Staphylococcus aureus Attachment on Medical Circulation Tubing under Static and Dynamic Flow Conditions.  ACS Appl. Bio Mater. 2020.

Research Funding

NIH logo

NSF logo

Boettcher logo

DOD logo

OEDIT logo

CSU logo

Contact

E-mail

Melissa.Reynolds@colostate.edu

Mailing Address

Department of Chemistry
Colorado State University
Fort Collins, CO 80523

Telephone

Office: 970-491-3775